Radiomic features define risk and are linked to DNA methylation attributes
... in primary CNS lymphoma
Recent publication
In a multicentre study, the use of radiological features to estimate the prognosis of primary central nervous system lymphoma (PCNSL) was investigated for the first time. Data from a total of 177 patients from nine Austrian centres and one Korean centre were integrated over a period of 13 years. The researchers developed a radiomic risk score based on imaging data, which proved to be a strong predictor of patient survival. The study not only demonstrated the clinical significance of radiomic analysis as a non-invasive marker for risk assessment in PCNSL, but also linked these radiomic features to epigenome-wide DNA methylation. This allows the identification of potential transcription factors as epigenetic treatment targets for specific patient subgroups. The integration of radiomics with molecular information offers a promising way to advance prognostic modelling and precision therapy for this aggressive brain tumour. The study has been published open access in the journal Neuro-Oncology Advances. It involved the Clinical Divisions of Neurosurgery and Neurology and the Institute of Clinical and Molecular Pathology at the University Hospital St. Pölten.
Nenning K-H, Gesperger J, Furtner J, Nemc A, Roetzer-Pejrimovsky T, Choi S-W et al. Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma. Neuro-Oncology Advances. 2023 Okt 18;5(1):vdad136. doi: 10.1093/noajnl/vdad136
The work was funded by the Austrian National Bank, the Austrian Science Fund, the Vienna Science and Technology Fund (WWTF) and Horizon Europe.
Prim. Clin. Ass. Prof. Dr. Melitta Kitzwögerer
Institute of Clinical Pathology and Molecular Pathology of the Lower Austria Central Region (University Hospital St. Pölten)
PD Dr. Franz Marhold
Division of Neurosurgery (University Hospital St. Pölten)
Prim. Assoc. Prof. PD Dr. Stefan Oberndorfer FEAN
Division of Neurology (University Hospital St. Pölten)
OA Dr. Florian Scheichel
Division of Neurosurgery (University Hospital St. Pölten)
Prim. Assoc. Prof. PD Dr. Camillo Sherif
Division of Neurosurgery (University Hospital St. Pölten)
