Home / Dr. Sonia Vallet

Dr. Sonia Vallet

Forschungsteam "Signal Transduction and the Tumor Microenvironment"

Vallet Sonia

Publikationen

  1. 2019

    • Konferenzbeitrag

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Bakiri, L., Wagner, E.F., Sattler, M., Pecherstorfer, M. & Podar, K., 2019. Combined targeting of distinct c-Myc and JunB transcriptional programs for multiple myeloma therapy. In 17th International Myeloma Workshop. Boston, S. 165.

    • Zeitschriftenartikel

      • Li, S., Vallet, S., Sacco, A., Roccaro, A., Lentzsch, S. & Podar, K., 2019. Targeting transcription factors in multiple myeloma: evolving therapeutic strategies. Expert opinion on investigational drugs, 28, S.445-462.

      • Lind, J., Czernilofsky, F., Vallet, S. & Podar, K., 2019. Emerging protein kinase inhibitors for the treatment of multiple myeloma. Expert opinion on emerging drugs, 24, S.133-152.

      • Vallet, S., Fan, F., Malvestiti, S., Pecherstorfer, M., Sattler, M., Schneeweiss, A., Schulze-Bergkamen, H., Opferman, J.T., Cardone, M.H., Jager, D. & Podar, K., 2019. Rationally derived drug combinations with the novel Mcl-1 inhibitor EU-5346 in breast cancer. Breast cancer research and treatment, 173, S.585-596.

  2. 2018

    • Konferenzbeitrag

      • Malvestiti, S., Fan, F., Bashari, H.M., Morelli, E., Seckinger, A., Hose, D., Goldschmidt, H., Zoernig, I., Bakiri, L., Sattler, M., Vallet, S., Pecherstorfer, M., Wagner, E.F., Tassone, P., Jaeger, D. & Podar, K., 2018. Multiple myeloma pathogenesis: The role of JunB in bone marrow angiogenesis. In 23rd Congress of the European Hematology Association (EHA). Stockholm, Sweden.

    • Zeitschriftenartikel

      • Vallet, S., Fan, F., Malvestiti, S., Pecherstorfer, M., Sattler, M., Schneeweiss, A., Schulze-Bergkamen, H., Opferman, J.T., Cardone, M.H., Jager, D. & Podar, K., 2018. Rationally derived drug combinations with the novel Mcl-1 inhibitor EU-5346 in breast cancer. Breast Cancer Research and Treatment.

      • Vallet, S., Filzmoser, J.M., Pecherstorfer, M. & Podar, K., 2018. Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies. Pharmaceutics, 10, S.202.

      • Vallet, S., Hoyle, N.R., Kyle, R.A., Podar, K. & Pecherstorfer, M., 2018. A role for bone turnover markers beta-CrossLaps (CTX) and amino-terminal propeptide of type I collagen (PINP) as potential indicators for disease progression from MGUS to multiple myeloma. Leukemia & Lymphoma, 59, S.2431-2438.

  3. 2017

    • Zeitschriftenartikel

      • Fan, F., Bashari, M.H., Morelli, E., Tonon, G., Malvestiti, S., Vallet, S., Jarahian, M., Seckinger, A., Hose, D., Bakiri, L., Sun, C., Hu, Y., Ball, C.R., Glimm, H., Sattler, M., Goldschmidt, H., Wagner, E.F., Tassone, P., Jaeger, D. & Podar, K., 2017. The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment. Leukemia, 31, S.1570-1581.

      • Rosenberger, F., Wiskemann, J., Vallet, S., Haag, G.M., Schembri, E., Jager, D. & Grüllich, C., 2017. Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy-a controlled feasibility trial. Support Care Cancer, 25, S.3655-3664.

      • Vallet, S., Pecherstorfer, M. & Podar, K., 2017. Adoptive cell therapy in multiple Myeloma. Expert Opinion on Biological Therapy, 17, S.1511-1522.

Forschungsprojekte

  • Biomarker-basierte therapeutische Prävention

    Biomarker-basierte therapeutische Prävention von Knochenmetastasen beim Mammakarzinom: Die pathophysiologische Rolle der endostalen Nische

    • Projektnummer: LSC18_010
    • Projektleitung: Sonia Vallet, Karl Landsteiner Privatuniversität für Gesundheitswissenschaften / Molekulare Hämatologie / Onkologie, Sonia Vallet, Karl Landsteiner Privatuniversität für Gesundheitswissenschaften / Klinische Abteilung für Innere Medizin 2 (UK Krems)
    • Projektpartner: IMC FH Krems / Department of Life Sciences
    • Projektlaufzeit: 36 Monate ab 01.12.2019

    Hintergrund

    Breast cancer (BC) is the most common malignancy in women. Most of the tumors are detected at early stages and treated with curative intent. However, up to one third of patients relapse, of which 70% develop bone metastases with survival rates dropping under 10% at 5 years. Efforts to find markers of bone metastases development have so far failed, mainly due to the poor understanding of early pathogenetic steps. Therefore, there remains a need for biomarkers that identify patients at high risk for bone metastases. In addition, despite the frequency of skeletal involvement and the associated morbidity and mortality, effective strategies to prevent bone metastases are lacking. Previous studies identified the endosteum as site of entry for bone metastatic BC cells, where OBs regulate tumor cell migration and survival. Specifically, our own data suggest a key role for pre-OBs in BC bone colonization. Here, I propose to unravel the pathophysiologic role of the endosteal niche, OB lineage cells in particular, during early phases of BM in BC by generating innovative in vitro models of OB differentiation.

Events

  1. 03 Mär

    Blutspendeaktion am Campus Krems

    03. März 2020, 11:30 - 16:30
    IMC FH Krems, Trakt G1, Erdgeschoß
  2. 05 Mär

    Symposion Dürnstein 2020

    05. März 2020, 18:00 - 07. März 2020, 16:00
    Stift Dürnstein, Prälatensaal, 3601 Dürnstein
  3. 09 Mär

    Teddybär Krankenhaus

    09. März 2020, 09:00 - 10. März 2020, 16:00
    Universitätsklinikum Krems, Mitterweg 10, 3500 Krems