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Projects

  • ACCESS POINT Oncology

    Molecular oncology research to develop new treatment strategies based on clinical (OIS) and biological (biobank) datasets

    • Project Number: K3- F-730/003-2020
    • Project Lead: Klaus Podar, Karl Landsteiner University of Health Sciences / Molecular Oncology / Hematology
    • Project Partner: Karl Landsteiner University of Health Sciences / Division of Internal Medicine 2 (University Hospital Krems), Karl Landsteiner University of Health Sciences / Division of Pharmakologie, FH St. Pölten / Institute for IT Security Research, MedAustron
    • Duration: 48 months starting from 01.01.2020
  • Biomarker- based therapeutic prevention

    Biomarker- based therapeutic prevention of bone metastases in breast cancer: Defining the pathophysiologic impact of the endosteal niche

    • Project Number: LSC18-010
    • Project Lead: Sonia Vallet, Karl Landsteiner University of Health Sciences / Molecular Oncology / Hematology, Sonia Vallet, Karl Landsteiner University of Health Sciences / Division of Internal Medicine 2 (University Hospital Krems)
    • Project Partner: IMC University of Applied Sciences Krems / Department of Life Sciences
    • Duration: 36 months starting from 01.12.2019

    Background

    Breast cancer (BC) is the most common malignancy in women. Most of the tumors are detected at early stages and treated with curative intent. However, up to one third of patients relapse, of which 70% develop bone metastases with survival rates dropping under 10% at 5 years. Efforts to find markers of bone metastases development have so far failed, mainly due to the poor understanding of early pathogenetic steps. Therefore, there remains a need for biomarkers that identify patients at high risk for bone metastases. In addition, despite the frequency of skeletal involvement and the associated morbidity and mortality, effective strategies to prevent bone metastases are lacking. Previous studies identified the endosteum as site of entry for bone metastatic BC cells, where OBs regulate tumor cell migration and survival. Specifically, our own data suggest a key role for pre-OBs in BC bone colonization. Here, I propose to unravel the pathophysiologic role of the endosteal niche, OB lineage cells in particular, during early phases of BM in BC by generating innovative in vitro models of OB differentiation.

  • JunB in multiple myeloma

    Pathophysiological role of JunB in multiple myeloma

    • Project Number: WST3-F-5031298/002-2018
    • Project Lead: Klaus Podar, Karl Landsteiner University of Health Sciences / Molecular Oncology / Hematology, Klaus Podar, Karl Landsteiner University of Health Sciences / Division of Internal Medicine 2 (University Hospital Krems)
    • Project Partner: The Antibody Lab GmbH, IMC University of Applied Sciences Krems, University of Veterinary Medicine Vienna / Institute for Pharmacology and Toxicology
    • Duration: 36 months starting from 01.10.2018

    Background

    Dieses Projekt wird aus Mitteln des Europäischen Fonds für regionale Entwicklung (EFRE) kofinanziert. Nähere Informationen zu IWB/EFRE finden Sie auf www.efre.gv.at
    Microenvironment-induced signaling pathways regulate the activity of numerous transcription factors (TFs). Approaches to target TFs are among the most promising novel anticancer strategies with a potentially high therapeutic index. Our recent data indicated a key role for the AP-1 family member JunB in MM pathogenesis (Fan et al., Leukemia 2017). In continuation of these findings, the proposed project aims to further define JunB as a novel therapeutic target in MM, and to thereby set the pace for the development of direct or indirect JunB inhibitors in order to further improve patient outcome.

Logo for the project: JunB in multiple myeloma

The project JunB in multiple myeloma is co-financed by the European Regional Development Fund (ERDF). Further information on IWB/EFRE: www.efre.gv.at

Events

  1. 02 Mar

    STUDENT TALK: Psychologie - in GERMAN only

    02. March 2021, 18:00 - 19:00
    Instagram Channel
  2. 09 Mar

    INFO TALK: Psychology - in GERMAN only

    09. March 2021, 18:00 - 19:00
    Online Chatroom: Microsoft Teams
  3. 13 Mar

    study INFO DAY

    13. March 2021, 10:00 - 15:00
    Online Event