Home / Priv. Doz. Dr. Sonia Vallet

Priv. Doz. Dr. Sonia Vallet

Working Group "Molecular Oncology/Hematology"

Senior Scientist, Attending Physician at University Hospital Krems

Publications

  1. 2021

    • Conference Paper

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Bakiri, L., Wagner, E.F., Sattler, M., Pecherstorfer, M. & Podar, K., 2021. Poster: Combined targeting of distinct c-Myc and JunB transcriptional programs for multiple myeloma therapy – Update. In OeGHO Frühjahrstagung. 8.-10.4.2021. Online, S. 23-41.

    • Journal Article

      • Fan, F., Malvestiti, S., Vallet, S., Lind, J., Garcia-Manteiga, J.Manuel, Morelli, E., Jiang, Q., Seckinger, A., Hose, D., Goldschmidt, H., Stadlbauer, A., Sun, C., Mei, H., Pecherstorfer, M., Bakiri, L., Wagner, E.F., Tonon, G., Sattler, M., Hu, Y., Tassone, P., Jaeger, D. & Podar, K., 2021. JunB is a key regulator of multiple myeloma bone marrow angiogenesis. Leukemia.

      • Singer, J., Le, N.-S., Mattes, D., Klamminger, V., Hackner, K., Kolinsky, N., Scherb, M., Errhalt, P., Kreye, G., Pecherstorfer, M., Vallet, S. & Podar, K., 2021. Evaluation of Antibody Responses to COVID-19 Vaccines among Solid Tumor and Hematologic Patients. Cancers, 13(17).

      • Zwickl, H., Zwickl-Traxler, E., Haushofer, A., Seier, J., Podar, K., Weber, M., Hackner, K., Jacobi, N., Pecherstorfer, M. & Vallet, S., 2021. Effect of cachexia on bone turnover in cancer patients: a case-control study. BMC Cancer, 21(1), S.744.

  2. 2020

    • Conference Paper

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Bakiri, L., Wagner, E.F., Sattler, M., Pecherstorfer, M. & Podar, K., 2020. Combined targeting of distinct c-Myc and JunB transcriptional programs for multiple myeloma therapy. In Abstractband für die Virtuelle Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 09.–11. Oktober 2020: Abstracts. 9.-11.10.2020. Online.

    • Other Scientific Contributions

      • Vallet, S., 2020. Kombinationstherapien in der Behandlung urogenitaler Tumoren. JATROS Hämatologie & Onkologie, (2).

  3. 2019

    • Conference Paper

      • Fan, F., Malvestiti, S., Shen, Y., Morelli, E., Mishima, Y., Seckinger, A., Hose, D., Bakiri, L., Vallet, S., Sattler, M., Roccaro, A.M., Goldschmidt, H., Percherstorfer, M., Sun, C., Hu, Y., Wagner, E.F., Tassone, P., Ghobrial, I.M., Jaeger, D. & Podar, K., 2019. Multiple Myeloma Pathogenesis: The Role of Junb in Bone Marrow Angiogenesis. In American Society of Hematology, 61th Annual Meeting, scientific session. Orlando, FL.

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Bakiri, L., Wagner, E.F., Sattler, M., Pecherstorfer, M. & Podar, K., 2019. Poster: Combined targeting of distinct c-Myc and JunB transcriptional programs for multiple myeloma therapy. In 17th International Myeloma Workshop. Boston.

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Sattler, M., Bakiri, L., Wagner, E.F., Percherstorfer, M. & Podar, K., 2019. Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy. In American Society of Hematology, 61th Annual Meeting, scientific session. Orlando, FL.

      • Pleyer, L., Pfeilstocker, M., Stauder, R., Heibl, S., Sill, H., Girschikofsky, M., Stampfl-Mattersberger, M., Tinchon, C., Petzer, A., Schmitt, C.A., Vallet, S., Mandac, I., Geissler, K., Sperr, W.R., Leisch, M., Egle, A., Melchardt, T., Fusinato, J., Piringer, G., Zebisch, A., Machherndl-Spandl, S., Wolf, D., Keil, F. & Greil, R., 2019. Expanding on Current Definitions of Hematologic Improvement in MDS, CMML and AML: Landmark Analyses of 1301 Patients Treated with Azacitidine in the Austrian Registry of Hypomethylating Agents By the AGMT-Study Group. In American Society of Hematology, 61th Annual Meeting, scientific session. Orlando, FL.

    • Journal Article

      • Li, S., Vallet, S., Sacco, A., Roccaro, A., Lentzsch, S. & Podar, K., 2019. Targeting transcription factors in multiple myeloma: evolving therapeutic strategies. Expert opinion on investigational drugs, 28, S.445-462.

      • Lind, J., Czernilofsky, F., Vallet, S. & Podar, K., 2019. Emerging protein kinase inhibitors for the treatment of multiple myeloma. Expert opinion on emerging drugs, 24, S.133-152.

      • Vallet, S., Fan, F., Malvestiti, S., Pecherstorfer, M., Sattler, M., Schneeweiss, A., Schulze-Bergkamen, H., Opferman, J.T., Cardone, M.H., Jager, D. & Podar, K., 2019. Rationally derived drug combinations with the novel Mcl-1 inhibitor EU-5346 in breast cancer. Breast cancer research and treatment, 173, S.585-596.

  4. 2018

    • Conference Paper

      • Malvestiti, S., Fan, F., Bashari, H.M., Morelli, E., Seckinger, A., Hose, D., Goldschmidt, H., Zoernig, I., Bakiri, L., Sattler, M., Vallet, S., Pecherstorfer, M., Wagner, E.F., Tassone, P., Jaeger, D. & Podar, K., 2018. Poster: Multiple myeloma pathogenesis: The role of JunB in bone marrow angiogenesis. In 23rd Congress of the European Hematology Association (EHA). Stockholm, Sweden.

    • Journal Article

      • Vallet, S., Filzmoser, J.M., Pecherstorfer, M. & Podar, K., 2018. Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies. Pharmaceutics, 10, S.202.

      • Vallet, S., Hoyle, N.R., Kyle, R.A., Podar, K. & Pecherstorfer, M., 2018. A role for bone turnover markers beta-CrossLaps (CTX) and amino-terminal propeptide of type I collagen (PINP) as potential indicators for disease progression from MGUS to multiple myeloma. Leukemia & Lymphoma, 59, S.2431-2438.

    • Other Scientific Contributions

      • Vallet, S., 2018. Checkpointblockade beim metastasierten Urothelkarzinom. JATROS Hämatologie & Onkologie, (2).

  5. 2017

    • Journal Article

      • Fan, F., Bashari, M.H., Morelli, E., Tonon, G., Malvestiti, S., Vallet, S., Jarahian, M., Seckinger, A., Hose, D., Bakiri, L., Sun, C., Hu, Y., Ball, C.R., Glimm, H., Sattler, M., Goldschmidt, H., Wagner, E.F., Tassone, P., Jaeger, D. & Podar, K., 2017. The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment. Leukemia, 31, S.1570-1581.

      • Rosenberger, F., Wiskemann, J., Vallet, S., Haag, G.M., Schembri, E., Jager, D. & Grüllich, C., 2017. Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy-a controlled feasibility trial. Support Care Cancer, 25, S.3655-3664.

      • Vallet, S., Pecherstorfer, M. & Podar, K., 2017. Adoptive cell therapy in multiple Myeloma. Expert Opinion on Biological Therapy, 17, S.1511-1522.

Research Projects

  • Biomarker- based therapeutic prevention

    Biomarker- based therapeutic prevention of bone metastases in breast cancer: Defining the pathophysiologic impact of the endosteal niche

    • Project Number: LSC18-010
    • Project Lead: Sonia Vallet, Karl Landsteiner University of Health Sciences / Molecular Oncology / Hematology, Sonia Vallet, Karl Landsteiner University of Health Sciences / Division of Internal Medicine 2 (University Hospital Krems)
    • Project Partner: IMC University of Applied Sciences Krems / Department of Life Sciences
    • Duration: 36 months starting from 01.12.2019

    Background

    Breast cancer (BC) is the most common malignancy in women. Most of the tumors are detected at early stages and treated with curative intent. However, up to one third of patients relapse, of which 70% develop bone metastases with survival rates dropping under 10% at 5 years. Efforts to find markers of bone metastases development have so far failed, mainly due to the poor understanding of early pathogenetic steps. Therefore, there remains a need for biomarkers that identify patients at high risk for bone metastases. In addition, despite the frequency of skeletal involvement and the associated morbidity and mortality, effective strategies to prevent bone metastases are lacking. Previous studies identified the endosteum as site of entry for bone metastatic BC cells, where OBs regulate tumor cell migration and survival. Specifically, our own data suggest a key role for pre-OBs in BC bone colonization. Here, I propose to unravel the pathophysiologic role of the endosteal niche, OB lineage cells in particular, during early phases of BM in BC by generating innovative in vitro models of OB differentiation.

Events

  1. 13 Nov

    study INFO DAY

    13. November 2021, 10:00 - 15:00
    Online Event
  2. 02 Jun
  3. 18 May

    ÖH Elections at KL University

    18. May 2021, 11:30 - 20. May 2021, 10:30
    Karl Landsteiner Privatuniversität, Trakt X / Besprechungsraum EG