Home / Priv.-Doz. Mag. DDr. Klaus Podar

Priv.-Doz. Mag. DDr. Klaus Podar

Head of Working Group "Molecular Oncology/Hematology"

Podar Klaus

Head of the Multiple Myeloma Program, Attending Physician at University Hospital Krems

Publications

  1. 2021

    • Conference Paper

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Bakiri, L., Wagner, E.F., Sattler, M., Pecherstorfer, M. & Podar, K., 2021. Poster: Combined targeting of distinct c-Myc and JunB transcriptional programs for multiple myeloma therapy – Update. In OeGHO Frühjahrstagung. 8.-10.4.2021. Online, S. 23-41.

      • Ludwig, H., Melchardt, T., Sormann, S., Schreder, M., Andel, J., Hartmann, B., Tinchon, C., Gunsilius, E., Podar, K., Egle, A., Willenbacher, W., Woll, E., Zojer, N., Ruckser, R., Bozic, B., Krauth, M.Theresa, Petzer, A., Schmitt, C.A., Machherndl-Spandl, S., Agis, H., Fillitz, M., Pönisch, W., Knop, S., Paiva, B. & Greil, R., 2021. Poster: Time to best response correlates with outcome in the randomized comparison between KRD and KTD followed by K maintenance or observation (AGMT-MM02 TRIAL). In EHA 2021 Virtual Congress. 9.-17.6.2021. Online, S. 325729; EP971.

    • Journal Article

      • Fan, F. & Podar, K., 2021. The Role of AP-1 Transcription Factors in Plasma Cell Biology and Multiple Myeloma Pathophysiology. Cancers, 13(10), S.2326.

      • Fan, F., Malvestiti, S., Vallet, S., Lind, J., Garcia-Manteiga, J.Manuel, Morelli, E., Jiang, Q., Seckinger, A., Hose, D., Goldschmidt, H., Stadlbauer, A., Sun, C., Mei, H., Pecherstorfer, M., Bakiri, L., Wagner, E.F., Tonon, G., Sattler, M., Hu, Y., Tassone, P., Jaeger, D. & Podar, K., 2021. JunB is a key regulator of multiple myeloma bone marrow angiogenesis. Leukemia.

      • John, L., Krauth, M.Theresa, Podar, K. & Raab, M.-S., 2021. Pathway-Directed Therapy in Multiple Myeloma. Cancers, 13(7), S.1668.

      • Lapidot, M., Case, A.E., Weisberg, E.L., Meng, C., Walker, S.R., Garg, S., Ni, W., Podar, K., Hung, Y.P., Carrasco, R.D., Knott, A., Gokhale, P.C., Sharma, S., Pozhitkov, A., Kulkarni, P., Frank, D.A., Salgia, R., Griffin, J.D., Saladi, S.V., Bueno, R. & Sattler, M., 2021. Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM). British journal of cancer.

      • Singer, J., Le, N.-S., Mattes, D., Klamminger, V., Hackner, K., Kolinsky, N., Scherb, M., Errhalt, P., Kreye, G., Pecherstorfer, M., Vallet, S. & Podar, K., 2021. Evaluation of Antibody Responses to COVID-19 Vaccines among Solid Tumor and Hematologic Patients. Cancers, 13(17).

      • Stadlbauer, A., Kinfe, T.M., Eyupoglu, I., Zimmermann, M., Kitzwögerer, M., Podar, K., Buchfelder, M., Heinz, G., Oberndorfer, S. & Marhold, F., 2021. Tissue hypoxia and alterations in microvascular architecture predict glioblastoma recurrence in humans. Clinical cancer research : an official journal of the American Association for Cancer Research.

      • Tremblay, G., Daniele, P., Breeze, J., Li, L., Shah, J., Shacham, S., Kauffman, M., Engelhardt, M., Chari, A., Nooka, A., Vogl, D., Gavriatopoulou, M., Dimopoulos, M.-A., Richardson, P., Biran, N., Siegel, D., Vlummens, P., Doyen, C., Facon, T., Mohty, M., Meuleman, N., Levy, M., Costa, L., Hoffman, J.E., Delforge, M., Kaminetzky, D., Weisel, K., Raab, M., Dingli, D., Tuchman, S., Laurent, F., Vij, R., Schiller, G., Moreau, P., Richter, J., Schreder, M., Podar, K., Parker, T., Cornell, R.Frank, Lionel, K., Choquet, S. & Sundar, J., 2021. Quality of life analyses in patients with multiple myeloma: results from the Selinexor (KPT-330) Treatment of Refractory Myeloma (STORM) phase 2b study. BMC Cancer, 21(1), S.993.

      • Zwickl, H., Zwickl-Traxler, E., Haushofer, A., Seier, J., Podar, K., Weber, M., Hackner, K., Jacobi, N., Pecherstorfer, M. & Vallet, S., 2021. Effect of cachexia on bone turnover in cancer patients: a case-control study. BMC Cancer, 21(1), S.744.

    • Other Scientific Contributions

      • Podar, K., 2021. Highlights beim Multiplen Myelom. krebs:hilfe!, (2), S.42-43.

  2. 2020

    • Conference Paper

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Bakiri, L., Wagner, E.F., Sattler, M., Pecherstorfer, M. & Podar, K., 2020. Combined targeting of distinct c-Myc and JunB transcriptional programs for multiple myeloma therapy. In Abstractband für die Virtuelle Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 09.–11. Oktober 2020: Abstracts. 9.-11.10.2020. Online.

      • Ludwig, H., Melchardt, T., Andel, J., Gunsilius, E., Sormann, S., Hinke, A., Hartmann, B.L., Podar, K., Willenbacher, W., Egle, A., Petzer, A., Zojer, N., Woll, E., Ruckser, R., Bozic, B., Schmitt, C.A., Machherndl-Spandl, S., Krauth, M.-T., Schreder, M., Agis, H., Tinchon, C., Fillitz, M. & Greil, R., 2020. Quality of Life in Newly Diagnosed Patients with Multiple Myeloma Randomized to Either Krd or Ktd Induction Therapy Followed By Carfilzomib Maintenance or Control (AGMT MM 02 trial). In Blood 136 (Suppl. 1). S. 27-29.

      • Ludwig, H., Sormann, S., Zojer, N., Andel, J., Hartmann, B.L., Tinchon, C., Gunsilius, E., Podar, K., Egle, A., Willenbacher, W., Woll, E., Ruckser, R., Bozic, B., Krauth, M.-T., Petzer, A., Schmitt, C.A., Machherndl-Spandl, S., Agis, H., Fillitz, M., Paiva, B. & Greil, R., 2020. Poster: Carfilzomib in combination with either Rd or Td overcomes the negative impact of HR cytogenetics in NDMM. Interim efficacy analysis of combined data of KRd vs. KTd followed by K maintenance or control. In 25th Congress of the European Hematology Association (EHA). COVID-19 Online.

    • Journal Article

      • Lapidot, M., Case, A.E., Larios, D., Gandler, H.I., Meng, C., Tosic, I., Weisberg, E.L., Poitras, M.J., Gokhale, P.C., Paweletz, C.P., Podar, K., Salgia, R., Saladi, S.V., Griffin, J.D., Frank, D.A., Bueno, R. & Sattler, M., 2020. Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM). Cancers, 13(1).

      • Manrique, I., Greil, R., Andel, J., Sormann, S., Hartmann, B.L., Podar, K., Egle, A., Petzer, A., Zojer, N., Ruckser, R., Bozic, B., Schmitt, C.A., Machherndl-Spandl, S., Agis, H., Schreder, M., Krauth, M.-T., Tinchon, C., Fillitz, M., Melchardt, T., Paiva, B. & Ludwig, H., 2020. Immunophenotyping of Baseline Bone Marrow Reveals a Specific Pattern of Immune Cells Associated with Greater Depth and Sustained Response in Newly Diagnosed Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Control (AGMT MM 02 Study. Blood, 136(Supplement 1), S.29-30.

      • Podar, K., Shah, J., Chari, A., Richardson, P.G. & Jagannath, S., 2020. Selinexor for the treatment of multiple myeloma. Expert opinion on pharmacotherapy, S.1-10.

    • Other Scientific Contributions

      • Podar, K., 2020. Multiples Myelom 2020 – was für Patienten erreicht wurde. krebs:hilfe!, (5), S.30-33.

      • Podar, K., 2020. Stellenwert der autologen Stammzelltransplantation beim multiplen Myelom. JATROS Hämatologie & Onkologie, (2), S.6-9.

  3. 2019

    • Conference Paper

      • Fan, F., Malvestiti, S., Shen, Y., Morelli, E., Mishima, Y., Seckinger, A., Hose, D., Bakiri, L., Vallet, S., Sattler, M., Roccaro, A.M., Goldschmidt, H., Percherstorfer, M., Sun, C., Hu, Y., Wagner, E.F., Tassone, P., Ghobrial, I.M., Jaeger, D. & Podar, K., 2019. Multiple Myeloma Pathogenesis: The Role of Junb in Bone Marrow Angiogenesis. In American Society of Hematology, 61th Annual Meeting, scientific session. Orlando, FL.

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Bakiri, L., Wagner, E.F., Sattler, M., Pecherstorfer, M. & Podar, K., 2019. Poster: Combined targeting of distinct c-Myc and JunB transcriptional programs for multiple myeloma therapy. In 17th International Myeloma Workshop. Boston.

      • Lind, J., Czernilofsky, F., Vallet, S., Fan, F., Sattler, M., Bakiri, L., Wagner, E.F., Percherstorfer, M. & Podar, K., 2019. Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy. In American Society of Hematology, 61th Annual Meeting, scientific session. Orlando, FL.

      • Ludwig, H., Sormann, S., Zojer, N., Andel, J., Hartmann, B.L., Tinchon, C., Gunsilius, E., Podar, K., Egle, A., Willenbacher, W., Woll, E., Ruckser, R., Bozic, B., Krauth, M.-T., Petzer, A., Schmitt, C.A., Machherndl-Spandl, S., Agis, H., Paiva, B. & Greil, R., 2019. Carfilzomib-Revlimid-Dexamethasone Vs. Carfilzomib-Thalidomide-Dexamethasone Weekly (After 2 Twice Weekly Cycles) Followed By Carfilzomib Maintenance Vs. Control in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma (NDMM) - Interim Ef. In American Society of Hematology, 61th Annual Meeting, scientific session. Orlando, FL.

      • Podar, K., 2019. Multiples Myelom II. In DGHO, OeGHO, SGMO & SGH 2019 (Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie). Berlin.

      • Podar, K., 2019. Präsentation: Klinisch relevante Arzneimittelinteraktionen im Multiplen Myelom. In Hämatologie im Wandel der Zeit . 28.-29.06.2019. Wien.

      • Podar, K., 2019. Präsentation: Stellenwert der Autologen Stammzelltransplantation beim Multiplen Myelom. In 9. Niederösterreichischer Onkologietag. Krems.

      • Podar, K., 2019. Presentation: Targeting transcription factors for cancer therapy: evolving therapeutic strategies . In 9. Niederösterreichischer Onkologietag. Krems.

    • Journal Article

      • Chari, A., Vogl, D.T., Gavriatopoulou, M., Nooka, A.K., Yee, A.J., Huff, C.A., Moreau, P., Dingli, D., Cole, C., Lonial, S., Dimopoulos, M., A. Stewart, K., Richter, J., Vij, R., Tuchman, S., Raab, M.S., Weisel, K.C., Delforge, M., Cornell, R.F., Kaminetzky, D., Hoffman, J.E., Costa, L.J., Parker, T.L., Levy, M., Schreder, M., Meuleman, N., Frenzel, L., Mohty, M., Choquet, S., Schiller, G., Comenzo, R.L., Engelhardt, M., Illmer, T., Vlummens, P., Doyen, C., Facon, T., Karlin, L., Perrot, A., Podar, K., Kauffman, M.G., Shacham, S., Li, L., Tang, S., Picklesimer, C., Saint-Martin, J.-R., Crochiere, M., Chang, H., Parekh, S., Landesman, Y., Shah, J., Richardson, P.G. & Jagannath, S., 2019. Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma. The New England journal of medicine, 381, S.727-738.

      • Li, S., Vallet, S., Sacco, A., Roccaro, A., Lentzsch, S. & Podar, K., 2019. Targeting transcription factors in multiple myeloma: evolving therapeutic strategies. Expert opinion on investigational drugs, 28, S.445-462.

      • Lind, J., Czernilofsky, F., Vallet, S. & Podar, K., 2019. Emerging protein kinase inhibitors for the treatment of multiple myeloma. Expert opinion on emerging drugs, 24, S.133-152.

      • Vallet, S., Fan, F., Malvestiti, S., Pecherstorfer, M., Sattler, M., Schneeweiss, A., Schulze-Bergkamen, H., Opferman, J.T., Cardone, M.H., Jager, D. & Podar, K., 2019. Rationally derived drug combinations with the novel Mcl-1 inhibitor EU-5346 in breast cancer. Breast cancer research and treatment, 173, S.585-596.

  4. 2018

    • Conference Paper

      • Malvestiti, S., Fan, F., Bashari, H.M., Morelli, E., Seckinger, A., Hose, D., Goldschmidt, H., Zoernig, I., Bakiri, L., Sattler, M., Vallet, S., Pecherstorfer, M., Wagner, E.F., Tassone, P., Jaeger, D. & Podar, K., 2018. Poster: Multiple myeloma pathogenesis: The role of JunB in bone marrow angiogenesis. In 23rd Congress of the European Hematology Association (EHA). Stockholm, Sweden.

      • Podar, K., 2018. Presentation: Transcription factors in multiple myeloma: new potential targets. In 4th Multiple Myeloma and related malignancies. Bari, Italy.

      • Podar, K., 2018. Therapiefortschritte – Hämato-Onkologie im Jahr 2018: Multiples Myelom. In 8. Niederösterreichischer Onkologietag. Krems.

    • Journal Article

      • Breitkreutz, I., Podar, K., Figueroa-Vazquez, V., Wilhelm, S., Hayden, P.J., Anderson, K.C. & Raab, M.S., 2018. The orally available multikinase inhibitor regorafenib (BAY 73-4506) in multiple myeloma. Annals of Hematology, 97, S.839-849.

      • Podar, K., 2018. Choosing an appropriate salvage therapy for a patient with multiple myeloma. Expert Opinion on Pharmacotherapy, 19, S.1511-1516.

      • Vallet, S., Filzmoser, J.M., Pecherstorfer, M. & Podar, K., 2018. Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies. Pharmaceutics, 10, S.202.

      • Vallet, S., Hoyle, N.R., Kyle, R.A., Podar, K. & Pecherstorfer, M., 2018. A role for bone turnover markers beta-CrossLaps (CTX) and amino-terminal propeptide of type I collagen (PINP) as potential indicators for disease progression from MGUS to multiple myeloma. Leukemia & Lymphoma, 59, S.2431-2438.

    • Other Scientific Contributions

      • Podar, K., 2018. Immunmodulierende Medikamente bleiben essenzielle Basis der Therapie. JATROS Hämatologie & Onkologie, (5), S.41.

      • Podar, K., 2018. Teamwork gegen Krebs. Gesund leben in Niederösterreich, (6), S.30-32.

  5. 2017

    • Journal Article

      • Bhanot, H., Weisberg, E.L., Reddy, M.M., Nonami, A., Neuberg, D., Stone, R.M., Podar, K., Salgia, R., Griffin, J.D. & Sattler, M., 2017. Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming. Oncotarget, 8, S.67639-67650.

      • Fan, F., Bashari, M.H., Morelli, E., Tonon, G., Malvestiti, S., Vallet, S., Jarahian, M., Seckinger, A., Hose, D., Bakiri, L., Sun, C., Hu, Y., Ball, C.R., Glimm, H., Sattler, M., Goldschmidt, H., Wagner, E.F., Tassone, P., Jaeger, D. & Podar, K., 2017. The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment. Leukemia, 31, S.1570-1581.

      • Podar, K. & Jager, D., 2017. Targeting the Immune Niche within the Bone Marrow Microenvironment: The Rise of Immunotherapy in Multiple Myeloma. Current Cancer Drug Targets, 17, S.782-805.

      • Podar, K. & Pecherstorfer, M., 2017. Current and developing synthetic pharmacotherapy for treating relapsed/refractory multiple myeloma. Expert Opinion on Pharmacotherapy, 18, S.1061-1079.

      • Vallet, S., Pecherstorfer, M. & Podar, K., 2017. Adoptive cell therapy in multiple Myeloma. Expert Opinion on Biological Therapy, 17, S.1511-1522.

Research Projects

  • STAT3

    STAT3 isoforms in hematopoietic disorders

    • Project Number: LSC19-019
    • Project Lead: Dagmar Stoiber-Sakaguchi, Karl Landsteiner University of Health Sciences / Division of Pharmakologie
    • Project Partner: Karl Landsteiner University of Health Sciences / Division of Internal Medicine 2 (University Hospital Krems), Medical University of Vienna / Institute of Pharmacology
    • Duration: 36 months starting from 01.01.2021

    Background

    Aberrant activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway
    is frequently associated with tumor development and the constitutive activation of STATs lies at the root of different
    hematopoietic malignancies. While several STAT members have been described to act as oncogenes, the transcription
    factor STAT3 serves as paradigm for tumorigenic signaling within this family. STAT3 has been described to promote
    proliferation as well as differentiation and it is the loss of transcriptional targets associated with differentiation, which is
    linked to the acquisition of tumorigenic potential.
    The goal of this project is to analyze the contribution of STAT3 isoforms to hematopoietic disorders. We plan to
    investigate how the shorter isoform, STAT3β, acts as tumor suppressor during acute myeloid leukemia,
    myelodysplastic syndrome as well as multiple myeloma. Furthermore, we aim to elucidate whether the balance of the
    two isoforms may help to predict patient outcome. This study is expected to shed light on the function of the shorter
    isoform STAT3β and STAT3-mediated control of leukocytes.

  • ACCESS POINT Oncology

    Molecular oncology research to develop new treatment strategies based on clinical (OIS) and biological (biobank) datasets

    • Project Number: K3- F-730/003-2020
    • Project Lead: Klaus Podar, Karl Landsteiner University of Health Sciences / Molecular Oncology / Hematology
    • Project Partner: Karl Landsteiner University of Health Sciences / Division of Internal Medicine 2 (University Hospital Krems), Karl Landsteiner University of Health Sciences / Division of Pharmakologie, FH St. Pölten / Institute for IT Security Research, MedAustron
    • Duration: 48 months starting from 01.01.2020
  • JunB in multiple myeloma

    Pathophysiological role of JunB in multiple myeloma

    • Project Number: WST3-F-5031298/002-2018
    • Project Lead: Klaus Podar, Karl Landsteiner University of Health Sciences / Molecular Oncology / Hematology, Klaus Podar, Karl Landsteiner University of Health Sciences / Division of Internal Medicine 2 (University Hospital Krems)
    • Project Partner: The Antibody Lab GmbH, IMC University of Applied Sciences Krems, University of Veterinary Medicine Vienna / Institute for Pharmacology and Toxicology
    • Duration: 36 months starting from 01.10.2018

    Background

    Dieses Projekt wird aus Mitteln des Europäischen Fonds für regionale Entwicklung (EFRE) kofinanziert. Nähere Informationen zu IWB/EFRE finden Sie auf www.efre.gv.at
    Microenvironment-induced signaling pathways regulate the activity of numerous transcription factors (TFs). Approaches to target TFs are among the most promising novel anticancer strategies with a potentially high therapeutic index. Our recent data indicated a key role for the AP-1 family member JunB in MM pathogenesis (Fan et al., Leukemia 2017). In continuation of these findings, the proposed project aims to further define JunB as a novel therapeutic target in MM, and to thereby set the pace for the development of direct or indirect JunB inhibitors in order to further improve patient outcome.

Events

  1. 13 Nov

    study INFO DAY

    13. November 2021, 10:00 - 15:00
    Online Event
  2. 02 Jun
  3. 18 May

    ÖH Elections at KL University

    18. May 2021, 11:30 - 20. May 2021, 10:30
    Karl Landsteiner Privatuniversität, Trakt X / Besprechungsraum EG