Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling
Recent Publication
A recent study involving researchers from the Department of Pharmacology provides new insights into the signalling pathways of immune cells. In addition to the known signalling pathway via STAT1, an alternative activation of STAT3 by interferon-γ was also demonstrated. This additional signalling component could play a role particularly in complex inflammatory situations. The results illustrate how complex the regulation of immune reactions is.
Botman, M., Huisman, J. M. A., Drakaki, A., Maas, S. L., Witalisz-Siepracka, A., Stoiber, D., van der Vorst, E. P. C., Siebeler, R., & Hoeksema, M. A. (2026). Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling. Cell Reports, 45(2), 116985. https://doi.org/10.1016/j.celrep.2026.116985
Univ.-Prof. PD MMag. Dr. Dagmar Stoiber-Sakaguchi
Head of
Department of Pharmacology
Agnieszka Witalisz-Siepracka PhD
Scientific Staff (PostDoc)
Department of Pharmacology