Muscle MRI quantifies disease progression in amyotrophic lateral sclerosis
Recent Publication
The diagnosis of ALS often brings uncertainty about the course of the disease - making it all the more important to have objective measurement methods that precisely record this. A research team, including Prim. Prof. Dr. Christian Nasel MSc PhD EDiINR, has now shown that muscle MRIs can do just that. Over the course of a year, changes in the muscle structure of ALS patients were visualized and reliably linked to the loss of muscle strength and function. Particularly impressive: the MRI data provided clear, reproducible indications of the progression of the disease.
Klickovic, U., Zampedri, L., Zafeiropoulos, N., Ziff, O. J., Sinclair, C. D., Wastling, S., Dudziec, M., Allen, J., Trimmel, K., Howard, R. S., Malaspina, A., Sharma, N., Sidle, K. C., Shah, S., Nasel, C., Yousry, T. A., Greensmith, L., Morrow, J. M., Thornton, J. S., & Fratta, P. (2025). Muscle MRI quantifies disease progression in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry. Advance online publication. https://doi.org/10.1136/jnnp-2024-335571
Prim. Univ.-Prof. Dr. Christian Nasel MSc PhD EDiINR
Institute of Diagnostic and Interventional Radiology (University Hospital Tulln)