Loss of STAT3 in Acute Myeloid Leukemia Favors Tissue Infiltration Linked to CXCR4 Signaling
Recent Publication
Researchers in the Division of Pharmacology have discovered that the loss of the STAT3 protein in acute myeloid leukaemia (AML) increases the spread of cancer cells to organs such as the liver and spleen. This effect was particularly strong in a subtype with certain gene mutations. The cause of this is the molecule CXCR4, which helps leukaemia cells to penetrate tissue like a ‘docking point’. Analyses of patient data confirmed that high CXCR4 levels mean a poorer prognosis. The results show that blocking STAT3 in therapy could have unexpectedly negative consequences.
Zdársky, B., Edtmayer, S., Witalisz-Siepracka, A., Weiss, S., Boigenzahn, S., Heindl, K., Zahma, S., Győrffy, B., Moriggl, R., & Stoiber, D. (Accepted/In press). Loss of STAT3 in Acute Myeloid Leukemia Favors Tissue Infiltration Linked to CXCR4 Signaling. Blood Neoplasia, 100158. https://doi.org/10.1016/j.bneo.2025.100158
Bernhard Zdársky PhD
Scientific Staff (PostDoc), Works Council
Department of Pharmacology
Sophie Rosa Edtmayer MSc PhD
Scientific Staff (PostDoc)
Department of Pharmacology
Agnieszka Witalisz-Siepracka PhD
Scientific Staff (PostDoc)
Department of Pharmacology
Kerstin Heindl MSc
Biomedical analyst
Department of Pharmacology
Univ.-Prof. PD MMag. Dr. Dagmar Stoiber-Sakaguchi
Head of
Department of Pharmacology