LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia
Recent Publication
A recent publication in the journal Nature Communications reveals new connections in the development of pre-eclampsia - a dangerous complication in pregnancy. Researchers have discovered that certain proteins (LAT1 and NRF2) in the body influence the balance of two important factors: sFlt-1 and PlGF. This imbalance can lead to problems. It has also been shown that the oxidative stress typical of pre-eclampsia is caused by impaired activity of these proteins.
Granitzer, S., Widhalm, R., Ellinger, I., Zeisler, H., Forsthuber, M., Foessleitner, P., Geschrey, E., Saleh, L., Knöfler, M., Desoye, G., Ettel, P., Weichhart, T., Musiejovsky, L., Schabbauer, G., Salzer, H., Rosner, M., Hengstschläger, M., & Gundacker, C. (2025). LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia. Nature Communications, 16(1), 9112. Article 9112. https://doi.org/10.1038/s41467-025-64160-0
OÄ Dr. Elisabeth Geschrey
Division of Gynaecology and Obstetrics (University Hospital St. Pölten)