Influence of heparin-based anticoagulants on antibiotic therapy
Recent Publication
Antibiotics are a key tool in medicine, but their effect can be influenced by other drugs. Researchers have investigated how various heparin-based anticoagulants affect the activity of antibiotics and natural antimicrobial substances in the blood. They found that certain types of heparin - especially unfractionated heparin and low-molecular-weight heparin - can significantly weaken the effect of some positively charged antibiotics. However, a third active substance, fondaparinux, did not show this negative effect. The reduced active levels mean that bacteria are more difficult to combat, which is particularly relevant in the fight against resistant germs.
Cont, D., Schildböck, C., Kolm, C., Kirschner, A. K. T., Farnleitner, A. H., Hartmann, J., Weber, V., & Harm, S. (2025). Influence of heparin-based anticoagulants on antibiotic therapy. Frontiers in Immunology, 16, 1708169. Article 1708169. https://doi.org/10.3389/fimmu.2025.1708169
Denisa Cont PhD
Scientific Staff (PostDoc)
Department of Physiology
Ass. Prof. DI Dr. Claudia Kolm Bakk
Scientific Staff (PostDoc)
Department of Water Quality and Health
Assoc. Prof. PD Mag. Dr. Alexander Kirschner
Scientific Staff (Sen. PostDoc)
Department of Water Quality and Health
Univ.-Prof. PD Dr. Andreas Farnleitner MSc
Head of
Department of Water Quality and Health