Autoclaved Peanuts Exhibit Reduced Immunoglobulin E Binding and Improved Oral Tolerability
Recent Publication
A recent study with the participation of Prim. Prof. Dr Thomas Eiwegger from the Scientific Working Group Clinical Immunology (KL) shows that autoclaved peanuts are significantly less allergenic than untreated peanuts. The treatment with heat and pressure changes important peanut allergens and breaks them down into smaller components. As a result, the proteins are much less likely to bind to IgE antibodies, which play a central role in allergic reactions. In skin tests and oral provocations, the people tested reacted much less strongly to autoclaved peanuts and tolerated larger quantities. The results suggest that this method could enable new and better tolerated approaches to immunotherapy for peanut allergies in the future.
Cohen, C. G., Toscano-Rivero, D., Ahmed, E. A., Al Ali, A., Zhao, W., Ke, D., Lejtenyi, D., Beaudette, L., Chazbey, H., Alrafiaah, A. S., Li, C. H., Dejgaard, K., Berghuis, A. M., Jean-Claude, B. J., McCusker, C., Eiwegger, T., Ben-Shoshan, M., & Mazer, B. D. (2026). Autoclaved Peanuts Exhibit Reduced Immunoglobulin E Binding and Improved Oral Tolerability. Allergy: European Journal of Allergy and Clinical Immunology. Advance online publication. https://doi.org/10.1111/all.70208
Prim. Univ.-Prof. PD Dr. Thomas Eiwegger
Scientific Working Group Clinical Immunology, Division of Paediatrics and Adolescent Medicine (University Hospital St. Pölten)