Autism-Linked Mutations in α2δ-1 and α2δ-3 Reduce Protein Membrane Expression but Affect Neither Calcium Channels nor Trans-Synaptic Signaling
Recent Publication
In a recent study, the role of genetic changes in the α2δ proteins associated with autism spectrum disorders (ASD) was investigated in more detail. These proteins are crucial for communication between nerve cells. The researchers discovered that two specific mutations in the α2δ proteins affect their normal function and position, but without disrupting the basic functions of the calcium channels. The study, which was conducted in the Department of Physiology and the PhD programme Mental Health and Neuroscience, was published in the journal ‘Pharmaceuticals’.
Haddad, S., Hessenberger, M., Ablinger, C., Eibl, C., Stanika, R., Campiglio, M., & Obermair, G. J. (2024). Autism-Linked Mutations in α2δ-1 and α2δ-3 Reduce Protein Membrane Expression but Affect Neither Calcium Channels nor Trans-Synaptic Signaling. Pharmaceuticals, 17(12), 1608. Artikel 1608. https://doi.org/10.3390/ph17121608
Dr. Manuel Hessenberger MSc
Scientific Staff (Sen. PostDoc), Safety Officer
Department of Physiology
Cornelia Ablinger, MSc.
Wiss. Mitarbeiterin (PhD) im Rahmen des CavX PhD Programms an der Medizinischen Universität Innsbruck
Department of Physiology
Dr. Ruslan Stanika
Scientific Staff (Sen. PostDoc)
Department of Physiology
Univ.-Prof. Mag. Dr. Gerald Obermair
Head of
PhD Programme Mental Health and Neuroscience, Department of Physiology