αKGDHC activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary cultures
Recent Publication
A current study involving Matej Hotka PhD from the Department of Physiology is investigating how an important enzyme influences nerve cell damage. The study shows that the activity of the enzyme αKGDHC plays a central role in the regulation of glutamate. If the enzyme is inhibited, harmful processes in nerve cells increase significantly. Conversely, increased activity of the enzyme can mitigate these effects. The results provide new approaches to better understand neuronal damage and possibly influence it therapeutically.
Goeschl, V., Hotka, M., Hochreiter, B., Hilber, K., Boehm, S., Kozlov, A. V., & Kubista, H. (Accepted/In press). αKGDHC activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary cultures. Journal of Cell Science. https://doi.org/10.1242/jcs.264420
Ing. Matej Hotka PhD
Scientific Staff (Sen. PostDoc)
Department of Physiology